抗Aggrecan抗体(anti-Aggrecan antibody)

　　名称：抗Aggrecan抗体(anti-Aggrecan antibody)

　　货号：FNab00213

　　适应种属：人源，小鼠，大鼠

　　规格：100ug(微克)

　　状态：液体

　　纯化方法：免疫亲和纯化

　　纯度：经sds-page分析，纯度大于95%

　　宿主：兔

　　亚型：IgG

　　存储：用添加了0.02%叠氮化钠和50%甘油的pbs溶解，ph值7.3，可在-20℃下保存12个月（避免反复冻融）

　　免疫原：aggrecan

　　免疫原别称：ACAN, AGC1, AGCAN, aggrecan, CSPG1, CSPGCP, MSK16, SEDK

　　分子量：70 kDa

　　验证应用：ELISA, WB, IHC

　　建议稀释比例：WB :1:500-1:1000; IHC: 1:20-1:200

　　克隆性：多克隆

　　uniprot id：P16112

　　背景介绍：Aggrecan (ACAN) , also named as CSPCP, AGC1 and MSK16, belongs to the aggrecan/versican proteoglycan family (also including versican, brevican and neurocan) . It is a major component of extracellular matrix of cartilagenous tissues. A major function of aggrecan is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. This polyclonal antibody raised against 1-298aa of human aggrecan reveals a band of 70 kDa, which is consistent with the molecular weight of degradation product generated by proteolysis at the aggrecanase site (PMID: 7852317; 9337874)。

　　Immunohistochemistry of paraffin-embedded human cartilage tissue slide using FNab00213 (ACAN Antibody) at dilution of 1:100。

　　ROS1728 cells were subjected to SDS PAGE followed by western blot with FNab00213 (ACAN Antibody) at dilution of 1:600。