抗SP1抗体(anti- SP1 antibody)

　　名称：抗sp1抗体(anti- sp1 antibody)

　　货号：fnab08131

　　适应种属：人源，小鼠，大鼠

　　规格：100ug(微克)

　　状态：液体

　　纯化方法：免疫亲和纯化

　　纯度：经sds-page分析,纯度大于95%

　　宿主：兔

　　亚型：igg

　　存储：用添加了0.02%叠氮化钠和50%甘油的pbs溶解,ph值7.3,可在-20℃下保存12个月（避免反复冻融）

　　免疫原：sp1 tranion factor

　　免疫原别称：sp1, sp1 tranion factor, tranion factor sp1, tsfp1

　　分子量：90kd

　　验证应用：elisa, wb, ip, ihc

　　建议稀释比例：wb: 1:500-1:2000; ip: 1:500-1:1000; ihc: 1:50-1:500; if: 1:20-1:200

　　克隆性：多克隆

　　uniprot id：p08047

　　背景介绍：tranion factor that can activate or repress tranion in response to physiological and pathological stimuli. binds with high affinity to gc-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation) . binds also the pdgfr-alpha g-box promoter. may have a role in modulating the cellular response to dna damage. implicated in chromatin remodeling. plays a role in the recruitment of smarca4/brg1 on the c-fos promoter. plays an essential role in the regulation of fe65 gene expression. in complex with atf7ip, maintains telomerase activity in cancer cells by inducing tert and terc gene expression. isoform 3 is a stronger activator of tranion than isoform 1. positively regulates the tranion of the core clock component arntl/bmal1。

　　图像：

　　immunohistochemistry of paraffin-embedded human lung cancer tissue using fnab08131 (sp1 antibody) at dilution of 1:50。

　　ip result of anti-sp1 (ip: fnab08131, 4ug; detection: fnab08131 1:500) with a431 cells lysate 2500ug。

　　jurkat cells were subjected to sds page followed by western blot with fnab08131 (sp1 antibody) at dilution of 1:500。