抗UBE3A抗体(anti- UBE3A antibody)

　　名称：抗ube3a抗体(anti- ube3a antibody)

　　货号：fnab09189

　　适应种属：人源，小鼠，大鼠

　　规格：100ug(微克)

　　状态：液体

　　纯化方法：免疫亲和纯化

　　纯度：经sds-page分析,纯度大于95%

　　宿主：兔

　　亚型：igg

　　存储：用添加了0.02%叠氮化钠和50%甘油的pbs溶解,ph值7.3,可在-20℃下保存12个月（避免反复冻融）

　　免疫原：ubiquitin protein ligase e3a

　　免疫原别称：ancr, as, e6 ap, e6ap, e6ap ubiquitin protein ligase, epve6ap, flj26981, hpve6a, ube3a, ubiquitin protein ligase e3a

　　分子量：110 kda

　　验证应用：elisa, wb, ihc

　　建议稀释比例：wb: 1:500 - 1:2000; ihc: 1:50 - 1:200

　　克隆性：多克隆

　　uniprot id：q05086

　　背景介绍：this gene encodes an e3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. this imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. maternally inherited deletion of this gene causes angelman syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. the protein also interacts with the e6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. alternative splicing of this gene results in three tran variants encoding three isoforms with different n-termini. additional tran variants have been described, but their full length nature has not been determined。

　　图像：

　　immunohistochemistry of paraffin-embedded human kidney using fnab09189(ube3a antibody) at dilution of 1:100。

　　mouse brain tissue were subjected to sds page followed by western blot with fnab09189(ube3a antibody) at dilution of 1:1000。