抗VAMP7/TI-VAMP抗体(anti- VAMP7/TI-VAMP antibody)

　　名称：抗VAMP7/TI-VAMP抗体(anti- VAMP7/TI-VAMP antibody)

　　货号：FNab09364

　　适应种属：人源，小鼠，大鼠

　　规格：100ug(微克)

　　状态：液体

　　纯化方法：免疫亲和纯化

　　纯度：经sds-page分析,纯度大于95%

　　宿主：兔

　　亚型：igg

　　存储：用添加了0.02%叠氮化钠和50%甘油的pbs溶解,ph值7.3,可在-20℃下保存12个月（避免反复冻融）

　　免疫原：vesicle-associated membrane protein 7

　　免疫原别称：SYBL1, Synaptobrevin like protein 1, Tetanus insensitive VAMP, TI VAMP, TI-VAMP, VAMP 7, VAMP7

　　分子量：20 kDa, 50 kDa

　　验证应用：ELISA, WB, IHC, IF

　　建议稀释比例：WB: 1:500-1:5000; IHC: 1:20-1:200；IF: 1:10-1:100; IP: 1:500-1:5000

　　克隆性：多克隆

　　uniprot id：P51809

　　背景介绍：VAMP7, also named as SYBL1 and TI-VAMP, belongs to the synaptobrevin family. It is involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. VAMP7 is required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. It is required for calcium regulated lysosomal exocytosis. VAMP7 is involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. It is required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. It is also required for focal exocytosis of late endocytic vesicles during phagosome formation. The antibody is specific to VAMP7。

　　图像：

　　Immunohistochemistry of paraffin-embedded human small intestine using FNab09364(VAMP7 antibody) at dilution of 1:50。

　　mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab09364(VAMP7 antibody) at dilution of 1:1000。