抗ACVR1B抗体(anti-ACVR1B antibody)

　　名称：抗acvr1b抗体(anti-acvr1b antibody)

　　货号：fnab00129

　　适应种属：人源，大鼠，小鼠

　　规格：100ug(微克)

　　状态：液体

　　纯化方法：免疫亲和纯化

　　纯度：经sds-page分析，纯度大于95%

　　宿主：兔

　　亚型：igg

　　存储：用添加了0.02%叠氮化钠和50%甘油的pbs溶解，ph值7.3，可在-20℃下保存12个月（避免反复冻融）

　　免疫原：activin a receptor, type ib

　　免疫原别称：activin a receptor, type ib, activin receptor like kinase 4, activin receptor type 1b, activin receptor type ib, actr ib, actrib, acvr1b, acvrlk4, alk 4, alk4, skr2

　　分子量：50 kda-70 kda

　　验证应用：elisa, wb, ihc

　　建议稀释比例：wb: 1:200-1:2000; ihc: 1:20-1:200

　　克隆性：多克隆

　　uniprot id：p36896

　　背景介绍：transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2(acvr2a or acvr2b). transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, fsh production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. within the receptor complex, type-2 receptors(acvr2a and/or acvr2b) act as a primary activin receptors whereas the type-1 receptors like acvr1b act as downstream transducers of activin signals. activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. the activated receptor type-2 then phosphorylates and activates the type-1 receptor such as acvr1b. once activated, the type-1 receptor binds and phosphorylates the smad proteins smad2 and smad3, on serine residues of the c-terminal tail. soon after their association with the activin receptor and subsequent phosphorylation, smad2 and smad3 are released into the cytoplasm where they interact with the common partner smad4. this smad complex translocates into the nucleus where it mediates activin-induced tranion. inhibitory smad7, which is recruited to acvr1b through fkbp1a, can prevent the association of smad2 and smad3 with the activin receptor complex, thereby blocking the activin signal. activin signal transduction is also antagonized by the binding to the receptor of inhibin-b via the igsf1 inhibin coreceptor. acvr1b also phosphorylates tdp2。

　　immunohistochemistry of paraffin-embedded human kidney using fnab00129(acvr1b antibody) at dilution of 1:100。

　　various lysates were subjected to sds page followed by western blot with fnab00129(acvr1b antibody) at dilution of 1:1000。