Anti-MYSM1 antibody LM84092R

anti-mysm1 antibody

产品描述

　　catalytic activity:ubiquitin c-terminal thioester + h(2)o = ubiquitin + a thiol. domain:binds double-stranded dna via the sant domain. the swirm domain does not bind double-stranded dna. metalloprotease that specifically deubiquitinates monoubiquitinated histone h2a, a specific tag for epigenetic tranional repression, thereby acting as a coactivator. preferentially deubiquitinates monoubiquitinated h2a in hyperacetylated nucleosomes. deubiquitination of histone h2a leads to facilitate the phosphorylation and dissociation of histone h1 from the nucleosome. acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (ar)-induced gene activation. ptm:phosphorylated upon dna damage, probably by atm or atr. belongs to the peptidase m67a family. mysm1 subfamily. contains 1 mpn (jab/mov34) domain. contains 1 sant domain. contains 1 swirm domain. subunit:component of a large chromatin remodeling complex, at least composed of mysm1, pcaf, rbm10 and kif11/trip5. binds histones.

　　产品名称anti-mysm1 antibody

　　分子量95 kda

　　种属反应性human

　　验证应用wb, ihc-p

　　抗ti类型兔多抗

　　免疫原the antiserum was produced against synthesized peptide derived from human mysm1. aa range:520-569

　　偶联non-conjugated

性能

　　形态liquid

　　浓度1 mg/ml.

　　存放说明store at +4℃ after thawing. aliquot store at -20℃ or -80℃. avoid repeated freeze / thaw cycles.

　　存储缓冲液liquid in pbs containing 50% glycerol, 0.5% bsa and 0.02% sodium azide.

　　亚型igg

　　纯化方式immunogen affinity purified.

　　数据链接swissprot: q5vvj2 human

　　其它名称

　　mysm1 antibody; kiaa1915 antibody; histone h2a deubiquitinase mysm1 antibody; 2a-dub antibody; myb-like antibody; swirm and mpn domain-containing protein 1 antibody;

应用

　　wb: 1:500-1:2000

　　ihc-p: 1:100-1:300

　　fig1: western blot analysis of various cells using mysm1 polyclonal antibody diluted at 1：2000 cells nucleus extracted by minute tm cytoplasmic and nuclear fractionation kit (sc-003,inventbiotech,mn,usa).

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