Anti-VEGF antibody LM80607R

Anti-VEGF antibody

产品描述

　　Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development.

　　产品名称Anti-VEGF antibody

　　分子量27 kDa

　　种属反应性Human

　　验证应用WB, ICC, IHC-P, FC

　　抗ti类型兔多抗

　　免疫原Synthetic peptide within N-terminal human VEGFA.

　　偶联Non-conjugated

性能

　　形态Liquid

　　浓度1 mg/mL.

　　存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

　　存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

　　亚型IgG

　　纯化方式Peptide affinity purified.

　　亚细胞定位Secreted.

　　数据链接SwissProt: P15692 Human

　　其它名称

　　Folliculostellate cell-derived growth factor antibody

　　Glioma-derived endothelial cell mitogen antibody

　　MGC70609 antibody

　　more

应用

　　WB: 1:500-1:1,000

　　ICC: 1:200

　　IHC-P: 1:200

　　FC: 1:100-1:200

本产品只适用于科研，不能用于临床诊断。严禁用于临床医疗及其他非科研用途！