Anti-MICA + MICB antibody 3198 LM880395R

　　mhc class i polypeptide-related sequence a/b (mica/b) is a cell surface glycoprotein encoded by the mica/b gene located within mhc locus. mica and micb are related to mhc class i and has similar domain structure, which is made up of external α1α2α3 domain, transmembrane segment and c-terminal cytoplasmic tail. mica/b rather functions as a stress-induced ligand for nkg2d receptor. mica is broadly recognized by nk cells, γδ t cells, and cd8+ αβ t cells which carry nkg2d receptor on their cell surface. as a result of nkg2d-mica engagement, effector cytolytic responses of t cells and nk cells against epithelial tumor cells expressing mica are initiated. mica/b are not associated with β2-microglobulin nor binds peptides as conventional mhc class i molecules do. the heat shock stress pathway is involved in the regulation of mica expression as tranion of mica is regulated by promoter heat shock element.

　　产品名称anti-mica + micb antibody [3198]

　　分子量42 kda

　　种属反应性human,mouse,rat

　　验证应用wb,icc,ihc-p

　　抗ti类型兔多抗

　　免疫原recombinant protein within human mica + micb aa 180-310.

　　偶联non-conjugated

　　性能

　　形态liquid

　　浓度1 mg/ml.

　　存放说明store at +4℃ after thawing. aliquot store at -20℃. avoid repeated freeze / thaw cycles.

　　存储缓冲液1*pbs (ph7.4), 0.2% bsa, 50% glycerol. preservative: 0.05% sodium azide.

　　亚型igg

　　纯化方式protein affinity purified.

　　亚细胞定位cell membrane. cytoplasm.

　　数据链接swissprot: q29980 human

　　swissprot: q29983 human

　　其它名称

　　mhc class i chain-related protein a antibody

　　mhc class i chain-related protein b antibody

　　mhc class i polypeptide related sequence a antibody

　　应用

　　wb:1:500-1:2,000

　　icc:1:50-1:100

　　ihc-p:1:50-1:200

　　本产品只适用于科研，不能用于临床诊断。严禁用于临床医疗及其他非科研用途！