Anti-NADPH oxidase 4 antibody LM851131R

　　The superoxide-generating NADPH oxidase includes a membrane-bound flavocytochrome containing two subunits, gp91-phox and p22-phox, and the cytosolic proteins p47-phox and p67-phox. During activation of the NADPH oxidase, p47-phox and p67-phox migrate to the plasma membrane where they associate with the flavocytochrome, cytochrome b558, to form the active enzyme complex. The p22 and gp91-phox subunits also function as surface O2 sensors that initiate cellular signaling in response to hypoxic conditions. Nox4 (also known as Renox) is a renal gp91-phox homolog highly expressed at the site of erythropoietin production in the proximal convoluted tubule epithelial cells of the renal cortex. Nox4 is also expressed in fetal tissues, placenta, glioblastoma and vascular cells. Like gp91-phox, the enzymatic activity of Nox4 produces superoxide anions. In vascular cells, the addition of Angiotensin II increases Nox4 expression, which suggests a role for Nox4 in vascular oxidative stress response. The gene encoding human Nox4 maps to chromosome 11q14.2-q21

　　产品名称Anti-NADPH oxidase 4 antibody

　　种属反应性Human, Mouse, Rat

　　验证应用ICC, IHC-P, FC

　　抗ti类型兔多抗

　　免疫原Synthetic peptide within C-terminal residues of NADPH oxidase 4.

　　偶联Non-conjugated

性能

　　形态Liquid

　　浓度1 mg/mL.

　　存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

　　存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

　　亚型IgG

　　纯化方式Peptide affinity purified.

　　亚细胞定位Cell membrane, Nucleus

　　数据链接Q9NPH5

　　其它名称

　　Kidney oxidase 1 antibody

　　Kidney oxidase-1 antibody

　　Kidney superoxide producing NADPH oxidase antibody

应用

　　ICC: 1:50-1:200

　　IHC-P: 1:50-1:200

　　FC: 1:10-1:100

本产品只适用于科研，不能用于临床诊断。严禁用于临床医疗及其他非科研用途！