Anti-Bad antibody LM851132R

Anti-Bad antibody

产品描述

　　The Bcl-2 family of proteins is characterized by its ability to modulate cell death (apoptosis) under a broad range of physiologic conditions. Bcl-2 and several related proteins function to inhibit apoptosis while other members of the Bcl-2 family, such as Bax and Bak, enhance cell death under various conditions. For instance, Bcl-xL represses cell death, while its shorter form, Bcl-xS, promotes apoptosis. A protein designated Bad exhibits homology to Bcl-2 limited to the BH1 and BH2 domains. Bad functions to dimerize with Bcl-xL and with Bcl-2, but not with Bax, Bcl-xS, Mcl-1, A1 or itself. In mammalian cells, Bad binds with greater affinity to Bcl-xL than to Bcl-2 and reverses the death repressor activity of Bcl-xL but not Bcl-2. Dimerization of Bad with Bcl-xL results in displacement of Bax from Bcl-xL:Bax complexes thereby causing restoration of Bax-mediated apoptosis.

　　产品名称Anti-Bad antibody

　　种属反应性Human

　　验证应用WB,ICC, IHC-P, FC

　　抗ti类型兔多抗

　　免疫原Synthetic peptide within N-terminal human Bad.

　　偶联Non-conjugated

性能

　　形态Liquid

　　浓度1 mg/mL.

　　存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

　　存储缓冲液1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

　　亚型IgG

　　纯化方式Peptide affinity purified.

　　亚细胞定位Mitochondrion outer membrane, Cytoplasm

　　数据链接Q92934

　　其它名称

　　AI325008 antibody

　　BAD antibody

　　BAD_HUMAN antibody

　　more

应用

　　ICC: 1:50-1:200

　　IHC-P: 1:50-1:200

　　FC: 1:50-1:200

本产品只适用于科研，不能用于临床诊断。严禁用于临床医疗及其他非科研用途！