Anti-HCAR2 antibody LM82290R

　　Anti-HCAR2 antibody

　　产品描述

　　developmental stage:Expression in neutrophils occurs in the late terminal differentiation phase. Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. miscellaneous:The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide. Belongs to the G-protein coupled receptor 1 family. tissue specificity:Expression largely restricted to adipose tissue and spleen. Expressed on mature neutrophils but not on immature neutrophils or eosinophils.

　　产品名称Anti-HCAR2 antibody

　　分子量39 kDa

　　种属反应性Human

　　验证应用WB

　　抗ti类型兔多抗

　　免疫原Synthesized peptide derived from human protein . at AA range: 260-340

　　偶联Non-conjugated

　　性能

　　形态Liquid

　　浓度1 mg/mL.

　　存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

　　存储缓冲液Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

　　亚型IgG

　　纯化方式Immunogen affinity purified.

　　数据链接SwissProt: Q8TDS4 Human

　　应用

　　wb: 1:500-1:2000

　　本产品只适用于科研，不能用于临床诊断。严禁用于临床医疗及其他非科研用途！