Anti-CD161/NK1.1 antibody LM890578R

　　Anti-CD161/NK1.1 antibody

　　产品描述

　　Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.

　　产品名称Anti-CD161/NK1.1 antibody

　　分子量25 KDa

　　种属反应性Human

　　验证应用WB

　　抗ti类型兔多抗

　　免疫原KLH conjugated synthetic peptide derived from human CD161/NK11 151-225/225

　　偶联Non-conjugated

　　性能

　　形态Liquid

　　浓度1 mg/mL.

　　存放说明Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.

　　存储缓冲液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

　　亚型IgG

　　纯化方式Protein A affinity purified.

　　亚细胞定位Membrane.

　　数据链接SwissProt: Q12918 Human

　　其它名称

　　CD161 antigen like family member C

　　CD161 antigen-like family member C

　　CD161c

　　more

　　应用

　　WB:1:500-2000

　　Fig1: Sample:

　　HepG2 (Human) CellLysate at 40 ug

　　MCF-7 (Human) CellLysate at 40 ug

　　Primary: Anti-CD161/NK1.1 at 1/300 dilution

　　Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution

　　Predicted band size: 25 kD

　　Observed band size: 25 kD

　　本产品只适用于科研，不能用于临床诊断。严禁用于临床医疗及其他非科研用途！