Anti-PTEN antibody LM870651R

Anti-PTEN antibody

产品描述

　　As human tumors progress to advanced stages, one genetic alteration that occurs at high frequency is a loss of heterozygosity (LOH) at chromosome 10q23. Mapping of homozygous deletions on this chromosome led to the isolation of the PTEN gene, also designated MMAC1 (for mutated in multiple advanced cancers) and TEP1. This candidate tumor suppressor gene exhibits a high frequency of mutations in human glioblastomas and is also mutated in other cancers, including sporadic brain, breast, kidney and prostate cancers. PTEN has been associated with Cowden disease, an autosomal dominant cancer predisposition syndrome. The PTEN gene product is a putative protein tyrosine phosphatase that is localized to the cytoplasm and shares extensive homology with the cytoskeletal proteins tensin and auxilin. Gene transfer studies have indicated that the phosphatase domain of PTEN is essential for growth suppression of glioma cells.

　　产品名称Anti-PTEN antibody

　　分子量47 kDa

　　种属反应性Human, Mouse

　　验证应用WB,ICC,IHC-P,FC

　　抗ti类型兔多抗

　　免疫原Recombinant protein within human PTEN aa 50-250.

　　偶联Non-conjugated

性能

　　形态Liquid

　　浓度1 mg/mL.

　　存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

　　存储缓冲液1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

　　亚型IgG

　　纯化方式Protein affinity purified.

　　亚细胞定位Nucleus. Cytoplasm. Secreted.

　　数据链接SwissProt: P60484 Human

　　SwissProt: O08586 Mouse

　　其它名称

　　10q23del antibody

　　BZS antibody

　　DEC antibody

　　more

应用

　　WB: 1:500

　　ICC: 1:100-1:500

　　IHC-P: 1:50-1:200

　　FC: 1:50-1:100

本产品只适用于科研，不能用于临床诊断。严禁用于临床医疗及其他非科研用途！