Anti-SKP2 antibody LM891662R

anti-skp2 antibody

产品描述

　　substrate recognition component of a scf (skp1-cul1-f-box protein) e3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and tranion. specifically recognizes phosphorylated cdkn1b/p27kip and is involved in regulation of g1/s transition. degradation of cdkn1b/p27kip also requires cks1. recognizes target proteins orc1, cdt1, rbl2, mll, cdk9, rag2, foxo1, ubp43, and probably myc, tob1 and tal1. degradation of tal1 also requires stub1. recognizes cdkn1a in association with ccne1 or ccne2 and cdk2. promotes ubiquitination and destruction of cdh1 in a ck1-dependent manner, thereby regulating cell migration.

　　产品名称anti-skp2 antibody

　　分子量48 kda

　　种属反应性human,mouse,rat,cow,rabbit

　　验证应用wb,ihc-p,fc

　　抗ti类型兔多抗

　　免疫原klh conjugated synthetic peptide derived from human skp2 351-424/424

　　偶联non-conjugated

性能

　　形态liquid

　　浓度1 mg/ml.

　　存放说明store at -20℃ for one year. avoid repeated freeze/thaw cycles. the lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. when reconstituted in sterile ph 7.4 0.01m pbs or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.

　　存储缓冲液0.01m tbs(ph7.4) with 1% bsa, 0.03% proclin300 and 50% glycerol.

　　亚型igg

　　纯化方式protein a affinity purified.

　　亚细胞定位cytoplasm. nucleus.

　　数据链接swissprot: q13309 human

　　其它名称

　　p45skp2

　　skp2p45

　　p45

　　more

应用

　　wb:1:500-2000

　　ihc-p:1:400-800

　　fc:1μg/test

本产品只适用于科研，不能用于临床诊断。严禁用于临床医疗及其他非科研用途！