Anti-p35 antibody LM84497R

Anti-p35 antibody

产品描述

　　The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.

　　产品名称Anti-p35 antibody

　　分子量38 kDa

　　种属反应性Human, Mouse, Rat

　　验证应用WB, IHC-P, IF

　　抗ti类型兔多抗

　　免疫原The antiserum was produced against synthesized peptide derived from human CDK5R1. AA range:11-60

　　偶联Non-conjugated

性能

　　形态Liquid

　　浓度1 mg/mL.

　　存放说明Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

　　存储缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

　　亚型IgG

　　纯化方式Immunogen affinity purified.

　　数据链接SwissProt: Q15078 Human

　　其它名称

　　CDK5R1 antibody; CDK5R antibody; NCK5A antibody; Cyclin-dependent kinase 5 activator 1 antibody; CDK5 activator 1 antibody; Cyclin-dependent kinase 5 regulatory subunit 1 antibody; TPKII regulatory subunit antibody;

应用

　　WB: 1:500-1:2000

　　IHC-P: 1:100-1:300

　　IF: 1:100-1:500

本产品只适用于科研，不能用于临床诊断。严禁用于临床医疗及其他非科研用途！