Anti-CBARA1 antibody LM880399R

　　anti-cbara1 antibody

　　产品描述

　　key regulator of mitochondrial calcium uniporter (mcu) that senses calcium level via its ef-hand domains. micu1 acts both as an activator or inhibitor of mitochondrial calcium uptake. the encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane ca2+ channel, and is essential in preventing mitochondrial ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. acts as a gatekeeper of mcu at low concentration of calcium, preventing channel opening. enhances mcu opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. induces t-helper 1-mediated autoreactivity, which is accompanied by the release of ifng. alternatively spliced tran variants encoding different isoforms have been described.

　　产品名称anti-cbara1 antibody

　　分子量45 kda

　　种属反应性human,mouse,rat

　　验证应用wb

　　抗ti类型兔多抗

　　免疫原recombinant protein within human cbara1 aa 14-154.

　　偶联non-conjugated

　　性能

　　形态liquid

　　浓度1 mg/ml.

　　存放说明store at +4℃ after thawing. aliquot store at -20℃. avoid repeated freeze / thaw cycles.

　　存储缓冲液1*pbs (ph7.4), 0.2% bsa, 50% glycerol. preservative: 0.05% sodium azide.

　　亚型igg

　　纯化方式protein affinity purified.

　　亚细胞定位mitochondrion.

　　数据链接swissprot: q9bpx6 human

　　swissprot: q8vcx5 mouse

　　swissprot: q6p6q9 rat

　　其它名称

　　allergen hom s 4 antibody

　　ara calc antibody

　　atopy related autoantigen antibody

　　more

　　应用

　　wb:1:500-1:2,000

　　fig1: western blot analysis of cbara1 on different lysates. proteins were transferred to a pvdf membrane and blocked with 5% bsa in pbs for 1 hour at room temperature. the primary antibody was used at a 1:500 dilution in 5% bsa at room temperature for 2 hours. goat anti-rabbit igg - hrp secondary antibody (ha1001) at 1:5,000 dilution was used for 1 hour at room temperature.

　　positive control:

　　lane 1: mouse kidney tissue lysate

　　lane 2: rat brain tissue lysate

　　lane 3: hela cell lysate

　　本产品只适用于科研，不能用于临床诊断。严禁用于临床医疗及其他非科研用途！