Anti-Bag-4 antibody LM82789R

anti-bag-4 antibody

产品描述

　　the protein encoded by this gene is a member of the bag1-related protein family. bag1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including bcl-2, raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kda family. this protein contains a bag domain near the c-terminus, which could bind and inhibit the chaperone activity of hsc70/hsp70. this protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (tnf-r1) and death receptor-3 (dr3), and thereby negatively regulates downstream cell death signaling. the regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. alternatively spliced tran variants encoding distinct

　　产品名称anti-bag-4 antibody

　　分子量50 kda

　　种属反应性human, mouse, rat

　　验证应用wb, ihc-p

　　抗ti类型兔多抗

　　免疫原synthesized peptide derived from the c-terminal region of human bag-4.

　　偶联non-conjugated

性能

　　形态liquid

　　浓度1 mg/ml.

　　存放说明store at +4℃ after thawing. aliquot store at -20℃ or -80℃. avoid repeated freeze / thaw cycles.

　　存储缓冲液liquid in pbs containing 50% glycerol, 0.5% bsa and 0.02% sodium azide.

　　亚型igg

　　纯化方式immunogen affinity purified.

　　数据链接swissprot: o95429 human

　　其它名称

　　bag4 antibody; sodd antibody; bag family molecular chaperone regulator 4 antibody; bag-4 antibody; bcl-2-associated athanogene 4 antibody; silencer of death domains antibody;

应用

　　wb: 1:500-1:2000

　　ihc-p: 1:100-1:300

　　fig1: western blot analysis of various cells using bag-4 polyclonal antibody

本产品只适用于科研，不能用于临床诊断。严禁用于临床医疗及其他非科研用途！