T细胞特异性表面糖蛋白CD28

　　产品编号: KMP2236

　　产品名称: Human Biotinylated CD28 Protein, Fc Tag, Avi Tag

　　中文名称: 生物素化重组人CD28蛋白

　　中文全称: 生物素化重组人T细胞特异性表面糖蛋白CD28蛋白

　　关键词: T细胞特异性表面糖蛋白CD28, CD28, CD28 molecule, Tp44, MGC138290, CD28 antigen, CD28 antigen(Tp44), T-cell-specific surface glycoprotein, Human Biotinylated CD28 Protein, Fc Tag, Avi Tag, Recombinant Protein, KMP2236

　　物种: Human

　　宿主: HEK293 Cells

　　规格: 50ug, 100ug, 200ug

　　纯化方式: Affinity purification

　　纯度: >95% as determined by SDS-PAGE

　　内毒素水平: <1.0 EU/ug determined by the LAL method

　　缓冲体系: 20mM Tris-HCl, 150mM NaCl, pH8.0

　　Uniprot: P10747

　　SDS-PAGE: KMP2236 SDS-PAGE image1.png

　　功能: Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933).

　　Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037).

　　产品背景: T-cell-specific surface glycoprotein CD28(CD28) is a single-pass typeI membrane protein which contains one Ig-likeV-type(immunoglobulin-like) domain. It belongs to the immunoglobulin(Ig) superfamily. CD28 is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 co-stimulation is necessary for CD4 positive T-cell proliferation and survival, interleukin-2 production, and T-helper type-2 development. Human post-thymic regulatory T cells require CD28 co-stimulation to expand and maintain potent suppressive function in vivo. Apoptosis plays a key role in the age-related decline of CD28 expression and in immunosenescence. CD28 is the receptor for CD80(B7.1) and CD86(B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells(APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.

　　保存条件: Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.

　　运输条件: In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.

　　说明: This product is for research use only.

　　参考文献: 1.J. Exp. Med. 199:1025-1031 (2004)

　　2.J. Immunol. 156:3133-3140