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　　LA-ICP-MS 是当今法医分析中最令人兴奋的分析技术之一，因为它可以在不进行任何样品预处理的情况下进行低至 ppb（十亿分之几）水平的超精密化学分析。分析可以在露天进行，不需要昂贵的真空设备，样品可以是导电的或不导电的。

　　LA-ICP-MS 提供所有分析程序中最快的分析速度，检测限接近 ppb 水平，因为数据可在几秒钟内获得。LA-ICP-MS 分析需要从纳克到飞克的亚微米级样品质量值。用于 ICP-MS 的传统液体雾化程序需要去除数毫克样品才能有效。

　　LA-ICP-MS 提供含量水平的元素组成测量，可在微小、低质量样品中进行可靠的样品区分。这些过程几乎不需要样品制备，并且通常需要不到 100 克的材料进行，从而确保宝贵的资源不会完全丢失。这允许您运行任意数量的测试。

　　低至 ppb 级别的灵敏度为犯罪学家提供了确定收集的证据如何适合每个案件所需的科学信息。发现很快，LA-ICP-MS 只需几分钟，这可能有助于许多实验室更快地管理样品积压。

　　使用 ICP-MS 或 LA-ICP-MS，并非所有法医样品都可以根据痕量元素分析轻松地相互分离。联邦研究局 (FBI) 对的元素分析进行了严格的调查，结果揭示了使用激光烧蚀进行微量元素分析以对进行法医的几个问题。

　　据估计，一颗 40 格令需要 12,000 到 3500 万铅。“组成相同数量的铅”可能用于制造 22 口径。许多生产商不定期地将制造过程中剩余的铅放入熔体中，导致原始熔体的成分偶尔发生变化。

　　激光烧蚀-ICP-MS 的未来展望

　　ICP-MS 设备已投放市场约 40 年，并已成为全球实验室的标准。随着目前对生态系统中微量元素的极大兴趣，显着商业化的时机已经到来。使用移动 LA-ICP-MS 也将有助于表征能源生产过程中产生的铀废料。

　　简而言之，LA-ICP-MS 是一种强大的仪器，可用于分析广泛的法医证据。这种方法对于克服极小的样品尺寸或由非反应性材料制成的样品的限制非常有用。LA-ICP-MS 根据微量元素比率数据生成明确的“指纹”，用于验证或排除法医证据的来源。使用适当的绘图应用程序，通常可以创建直接可视的数据形式，从而更容易区分样本。

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　　LA-ICP-MS is one of the most exciting analytical technologies in forensic analysis nowadays since it can do ultra-highly delicate chemical analysis down to ppb (parts per billion) levels without any sample pretreatment. The analysis may be carried out in the open air without the need for expensive vacuum apparatus, and the samples can be conductive or non-conductive.

　　LA-ICP-MS offers the fastest analysis speed of all analytical procedures, with a limit of detection near the ppb level, since the data are available in seconds. Sub-microscale sample mass values ranging from nanograms to femtograms are required for LA-ICP-MS analysis. Traditional liquid nebulization procedures for ICP-MS need the removal of milligrams of sample mass to be effective.

　　LA-ICP-MS provides elemental composition measurements at content levels that allow for robust sample discrimination among tiny, low-mass samples. These processes need little to no specimen preparation and often require less than 100 g of material for evaluation, ensuring that precious resources are not lost entirely. This allows you to run as many tests as you like.

　　Sensitivity down to the ppb level provides criminologists with the scientific information they need to determine how the evidence collected fits into each case. The findings are swift, requiring just a few minutes for LA-ICP-MS, which might help many labs manage sample backlogs faster.

　　Limitations

　　Using ICP-MS or LA-ICP-MS, not all forensic samples can be easily separated from one another based on trace elemental analysis. The Federal Bureau of Research (FBI) conducted a rigorous investigation into the elemental analysis of bullet lead, which revealed several issues with the use of laser ablation for trace element analysis for the forensic evaluation of lead bullets.

　　It was estimated that a 40-grain bullet would need anything from 12,000 to 35 million lead. "Compositionally identical amounts of lead" might be used to make a 22 caliber long gun. Many bullet producers put leftover lead from bullet manufacturing into the melt at odd periods, causing the original melt's composition to occasionally shift.

　　Future Perspectives of Laser Ablation-ICP-MS

　　ICP-MS devices have been on the marketplace for about 40 years and have established themselves as standard in laboratories worldwide. With the present great interest in trace element evaluation in the ecosystem, the time has come for significant commercialization. The use of mobile LA-ICP-MS will also aid in the characterization of uranium waste generated during energy production.

　　In short, LA-ICP-MS is a powerful instrument for analyzing a broad range of forensic evidence. This approach is very useful for overcoming the restrictions of extremely tiny sample sizes or samples made of unreactive materials. LA-ICP-MS produces a definite "fingerprint" based on trace element ratio data that is used to validate or exclude the origin of forensic evidence. Using a proper plotting application, a direct visual form of data is often created, making it simpler to distinguish samples.