富马酸单甲酯

　　中文名称富马酸单甲酯

　　中文同义词

　　富马酸单甲酯;富马酸单甲酯,97%+;富马酸单甲基酯;富马酸单甲酯5G;(E)-2-;富马酸单甲酯;富马酸单甲酯标准品;(E)-4-甲氧基-4-氧代丁基-2-烯酸

　　英文名称Monomethylfumarate

　　英文同义词(E)-2-Butenedioicacidhydrogen1-methylester;Fumaricacidhydrogen1-methylester;Monomethyltrans-ethylene-1,2-dicarboxylate;Monomethylfumarate;Methylhydrogenfumarate;Fumaricacidmonomethylester;mono-Methylfumarate,Fumaricacidmonomethylester,Methylhydrogenfumarate;(2E)-4-Methoxy-4-oxobut-2-enoicacid

　　CAS号2756-87-8

　　分子式C5H6O4

　　分子量130.1

　　EINECS号220-412-6

　　熔点144-145°C(lit.)

　　沸点250.0±23.0°C(Predicted)

　　密度1.37g/cm3

　　储存条件2-8°C

　　溶解度Chloroform(Slightly),DMSO(Slightly),Methanol(Slightly)

　　酸度系数(pKa)3.40±0.10(Predicted)

　　形态Solid

　　颜色Off-White

　　波长(λmax)209nm(MeOH)(lit.)

　　CAS数据库2756-87-8(CASDataBaseReference)

　　体外研究

　　MonomethylfumaratecompletelyinhibitsforskolininducedcAMPsynthesiswithanIC50of70nM.Monomethylfumarateinducesadose-dependentCa2+signalinGPR109AtransfectedcellswithanECChemicalbook50of9.4μM.Monomethylfumarate(25μM;24hours)attenuates7β-OHC-inducedcytotoxicity:cellgrowthinhibition;decreasedcellviability;mitochondrialdysfunction;andcelldeathinduction.

　　体内研究

　　AsingledoseofMonomethylfumarate(50-100mg/kg;IP)beforelightexposurepreventsthesemorphologicchanges(brightlightexposureinducedphotoreceptordeath)inadose-dependentmanner.Monomethylfumarate(100mg/kg)reducesretinalinflammationandoxidativestress.MonomethylfumaratesignificantlysuppressesligChemicalbookht-inducedretinopathy(LIR)upregulatedgenesintheNFkBpathwayincluding:Nlrp3,Casp1,Il-1β,andTnf-α.AnimalModel:AlbinoBALB/cmice(male,6weeksold)Dosage:50,65,75,100mg/kgAdministration:IPResult:Preventedthesemorphologicchanges(brightlightexposureinducedphotoreceptordeath)inadose-dependentmanner.